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Francis Giles Selected Research

troxacitabine

1/2007A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma.
10/2006Troxacitabine in leukemia.
4/2006Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue.
1/2002Fatal hepatic veno-occlusive disease in a phase I study of mylotarg and troxatyl in patients with refractory acute myeloid leukemia or myelodysplastic syndrome.

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Francis Giles Research Topics

Disease

58BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2017 - 10/2002
33Neoplasms (Cancer)
01/2021 - 03/2003
31Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2021 - 01/2002
28Philadelphia Chromosome
08/2016 - 01/2003
23Myelodysplastic Syndromes (Myelodysplastic Syndrome)
06/2009 - 01/2002
21Leukemia
01/2020 - 10/2002
13Hematologic Neoplasms (Hematological Malignancy)
01/2021 - 09/2002
10Primary Myelofibrosis (Myelosclerosis)
01/2015 - 09/2002
9Multiple Myeloma
01/2021 - 03/2003
9B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
03/2008 - 09/2002
9Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/2007 - 10/2003
8Myeloproliferative Disorders (Myeloproliferative Disorder)
11/2007 - 09/2002
5Lymphoma (Lymphomas)
01/2020 - 02/2004
4Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
06/2007 - 06/2003
4Acute Promyelocytic Leukemia
12/2006 - 11/2003
4Chromosome Aberrations (Chromosome Abnormalities)
02/2006 - 03/2003
3Hairy Cell Leukemia
01/2021 - 09/2002
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019 - 01/2017
3Adenocarcinoma
01/2017 - 11/2008
3Carcinogenesis
12/2011 - 02/2007
3Blast Crisis (Blast Phase)
12/2008 - 08/2006
3Polycythemia Vera
11/2007 - 06/2003
3Disease Progression
11/2007 - 06/2005
3Essential Thrombocythemia
11/2007 - 06/2005
3Thrombocytopenia (Thrombopenia)
05/2007 - 02/2004
3Anemia
08/2006 - 06/2004
3Diarrhea
01/2006 - 08/2002
3Fibrosis (Cirrhosis)
08/2005 - 07/2004
2Breast Neoplasms (Breast Cancer)
10/2016 - 12/2015
2Hepatocellular Carcinoma (Hepatoma)
12/2015 - 04/2011
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
10/2009 - 07/2007
2Sarcoma (Soft Tissue Sarcoma)
10/2009 - 12/2008
2Pneumonia (Pneumonitis)
04/2009 - 01/2003
2Lymphoproliferative Disorders (Lymphoproliferative Disorder)
12/2007 - 01/2007
2Pathologic Complete Response
11/2004 - 09/2004
2Fever (Fevers)
02/2004 - 01/2003
2Mycoses (Diseases, Fungus)
02/2004 - 01/2003

Drug/Important Bio-Agent (IBA)

49Imatinib Mesylate (Gleevec)FDA Link
09/2009 - 01/2003
14nilotinibFDA Link
01/2017 - 07/2005
13Cytarabine (Cytosar-U)FDA LinkGeneric
04/2012 - 08/2002
10Interferon-alpha (Interferon Alfa)IBA
11/2007 - 07/2003
8Proteins (Proteins, Gene)FDA Link
01/2021 - 09/2002
8Pharmaceutical PreparationsIBA
01/2017 - 11/2003
8Tyrosine Kinase InhibitorsIBA
08/2016 - 09/2003
7Phosphotransferases (Kinase)IBA
12/2008 - 01/2005
6InterferonsIBA
01/2007 - 07/2003
5Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric
04/2012 - 08/2002
5laromustine (VNP40101M)IBA
11/2009 - 05/2004
5fludarabineIBA
12/2007 - 03/2003
5Topotecan (Hycamtin)FDA LinkGeneric
05/2007 - 03/2003
5Gemtuzumab (Mylotarg)FDA Link
07/2006 - 01/2002
4NEO2734IBA
08/2021 - 01/2020
4Immune Checkpoint InhibitorsIBA
01/2019 - 01/2017
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2011 - 01/2006
4Biological ProductsIBA
10/2009 - 05/2004
4Dasatinib (BMS 354825)FDA Link
06/2008 - 01/2007
4bcr-abl Fusion ProteinsIBA
02/2008 - 07/2007
4TransferasesIBA
11/2007 - 03/2003
4Tretinoin (Retinoic Acid)FDA LinkGeneric
10/2007 - 02/2004
4Alkylating AgentsIBA
01/2007 - 05/2004
4troxacitabineIBA
01/2007 - 01/2002
3Messenger RNA (mRNA)IBA
01/2019 - 02/2007
3Monoclonal AntibodiesIBA
01/2018 - 06/2005
3Proteasome Endopeptidase Complex (Proteasome)IBA
04/2011 - 03/2008
3tipifarnib (R115777)IBA
11/2007 - 03/2003
3Hemoglobins (Hemoglobin)IBA
08/2006 - 06/2004
3Reticulin (Reticular Fiber)IBA
08/2005 - 07/2004
3Rituximab (Mabthera)FDA Link
06/2005 - 11/2003
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2005 - 12/2004
2immunotoxin HA22IBA
01/2021 - 01/2018
2Biomarkers (Surrogate Marker)IBA
01/2019 - 11/2017
2Glycogen Synthase Kinase 3IBA
01/2019 - 10/2016
2RNA (Ribonucleic Acid)IBA
01/2019 - 02/2007
2NivolumabIBA
01/2018 - 01/2017
2IpilimumabIBA
01/2018 - 01/2017
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
10/2016 - 12/2011
2UbiquitinIBA
04/2011 - 03/2008
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2009 - 07/2003
2Alemtuzumab (Campath)FDA Link
12/2007 - 11/2005
2Azacitidine (5 Azacytidine)FDA Link
10/2007 - 05/2007
2Lenalidomide (CC 5013)FDA Link
05/2007 - 08/2006
2DecitabineFDA Link
05/2007 - 01/2007
2HomoharringtonineIBA
01/2007 - 09/2003
2Arsenic Trioxide (Trisenox)FDA Link
12/2006 - 09/2004
2Histone Deacetylase InhibitorsIBA
08/2006 - 07/2006
2PanobinostatIBA
08/2006 - 07/2006
22-aminopyrimidineIBA
09/2005 - 07/2005
2fms-Like Tyrosine Kinase 3IBA
01/2005 - 05/2004
2AnthracyclinesIBA
09/2004 - 08/2002
2CytokinesIBA
06/2004 - 09/2002
2Bortezomib (Velcade)FDA Link
05/2004 - 04/2004
2DNA (Deoxyribonucleic Acid)IBA
04/2004 - 09/2003
2Fluconazole (Zonal)FDA LinkGeneric
02/2004 - 01/2003
2Itraconazole (Sporanox)FDA LinkGeneric
02/2004 - 01/2003

Therapy/Procedure

75Therapeutics
01/2019 - 01/2003
14Drug Therapy (Chemotherapy)
01/2020 - 03/2003
4Stem Cell Transplantation
07/2007 - 07/2003
3Induction Chemotherapy
11/2004 - 01/2003
2Immunotherapy
01/2018 - 01/2017
2Combination Drug Therapy (Combination Chemotherapy)
01/2017 - 05/2007